Last updated on 24 September 2025 by Brisbane Livewell Clinic Editorial Team
Pyrrole Disorder: Understanding and Managing Elevated HPL Levels
Pyrrole disorder, also known as elevated hydroxyhemopyrrolin-2-one (HPL) or Mauve Factor, is a biochemical imbalance that may impact overall health. Elevated HPL levels in the urine can deplete essential nutrients, particularly Zinc and Vitamin B6, leading to various symptoms and associated conditions.
Addressing these imbalances through testing and targeted treatment can significantly improve your health (including your mental health) and well-being.
Key Takeaways
- Pyrrole disorder involves elevated levels of HPL, depleting Zinc and Vitamin B6
- Commonly associated conditions include anxiety, ADHD, and depression
- Symptoms vary from neurological to digestive and dermatological issues
- Accurate testing and tailored treatment are essential for effective management.
What is Pyrrole Disorder?
Pyrrole disorder is characterised by elevated HPL levels in the urine, which can lead to nutrient depletion and oxidative stress. While everyone produces small amounts of pyrrole, excessive levels can result in chronic nutrient deficiencies and related health challenges.
The condition is not widely recognised in mainstream medicine but is often identified through functional and naturopathic testing.
Associated Conditions
While not everyone with pyrrole disorder experiences related conditions, the disorder has been linked to the following:
- ADHD
- Autism
- Anxiety and depression
- Bipolar disorder
- Schizophrenia
- Learning disabilities
- Epilepsy
- Alcoholism
Research also suggests that elevated HPL levels may contribute to behavioural and cognitive challenges, particularly in high-stress environments.
Symptoms of Pyrrole Disorder
Symptoms of pyrrole disorder can vary in intensity and often mimic other health issues. They can be grouped into the following categories:
1. Neurological Symptoms
- Anxiety and irritability
- Brain fog and poor memory
- Sensitivity to light, sound, and smells
- Stress intolerance
2. Digestive Symptoms
- Nausea or lack of appetite
- Diarrhoea or constipation
- Leaky gut syndrome
3. Skin, Hair, and Nails
- Dry, itchy skin and dermatitis
- Premature greying or stretch marks
- White spots on nails (a sign of zinc deficiency)
Testing for Pyrrole Disorder
Testing for pyrrole disorder involves a specialised urine test that measures HPL levels. This test must be conducted under specific conditions to ensure accuracy:
- Urine samples must be collected from the second void of the day or later.
- Samples must be frozen immediately and protected from light and heat.
Additional testing of Zinc, Copper, and Ceruloplasmin through blood tests provides a more comprehensive assessment of nutrient imbalances.
Why Accurate Testing Matters
Baseline measurements of essential nutrients, such as Zinc and Vitamin B6, help monitor progress and prevent toxicity. Retesting ensures that treatments are effective and that ongoing deficiencies are managed appropriately.
In the Experience of Our Naturopaths
Our Naturopaths have extensive experience supporting patients with pyrrole disorder. They understand that each patient’s symptoms, history, and lifestyle factors influence their health outcomes.
During consultations, our Naturopaths thoroughly assess your health, focusing on patterns of symptoms that may suggest nutrient deficiencies or elevated pyrrole levels.
Wellness Plans are customised to address your unique needs. From nutritional guidance to supplement protocols, our Naturopaths work with you to reduce symptoms and support overall well-being.
Patients often report improvements in mood, energy levels, and stress tolerance after beginning treatment. Regular follow-ups ensure ongoing support and adjustments to your Wellness Plan, keeping you on track toward better health.
Treatment Approaches
Treatment for Pyrrole Disorder focuses on replenishing depleted nutrients and addressing individual health needs. The primary nutrients used include:
- Zinc: Essential for immune function, cognitive health, and skin repair
- Vitamin B6: Supports neurological health and mood regulation
Additional supplements, such as Omega-3 fatty acids and antioxidants, may be recommended.
The Wellness Plan is tailored to each patient, with dosage adjustments based on ongoing testing and symptom improvement.
Things to Know About Pyrrole Disorder
- Elevated pyrrole levels can be temporary, particularly during stress or digestive issues, but require treatment if sustained
- Some patients achieve resolution with targeted treatment, while others may need ongoing supplementation
- Improvements in testing methods and reference ranges mean a reassessment of previous diagnoses is often beneficial
The Importance of Personalised Care
The principle of “Treat the Individual” is central to Pyrrole Disorder management. While general protocols exist, each patient’s unique symptoms, test results, and health goals guide treatment decisions.
Conclusion
Pyrrole Disorder can significantly affect health and well-being if left untreated. Accurate testing, tailored treatment, and regular follow-ups with a qualified Naturopath are essential to address nutrient deficiencies and reduce symptoms effectively.
So book an Initial Naturopath Consultation with one of our skilled Naturopaths today.
FAQs
1. What is pyrrole disorder?
Pyrrole disorder involves elevated HPL levels in the urine, leading to nutrient depletion of Zinc and Vitamin B6. It is linked to symptoms such as anxiety, depression, and poor memory.
2. How is pyrrole disorder diagnosed?
Diagnosis is made through urine testing for HPL levels and blood tests for Zinc, Copper, and Ceruloplasmin. Samples must be frozen immediately to ensure accurate results.
3. Can pyrrole disorder be cured?
Some patients achieve resolution with targeted treatment, while others require ongoing supplementation to manage symptoms and nutrient deficiencies.
4. What are common symptoms of pyrrole disorder?
Symptoms include anxiety, brain fog, poor memory, digestive issues, dry skin, and white spots on nails. Symptoms vary in severity among individuals.
5. Why is Zinc important for pyrrole disorder?
Zinc helps address the deficiencies caused by elevated pyrrole levels, supporting immune function, skin repair, and cognitive health.
6. How is Vitamin B6 used in treatment?
Vitamin B6 replenishes deficiencies, supporting mood regulation and neurological health. It is often prescribed in specific doses for pyrrole disorder.
7. Can pyrrole disorder affect mental health?
Pyrrole disorder is linked to conditions like anxiety, depression, and bipolar disorder due to its impact on neurological function and nutrient depletion.
8. Is testing for pyrrole disorder covered by Medicare?
Testing for pyrrole disorder is not available through a GP or Medicare. Private testing is required, which can be arranged through your Naturopath at Brisbane Livewell Clinic.
9. Can diet help manage Pyrrole Disorder?
A nutrient-rich diet can support overall health but may not fully address the deficiencies caused by elevated pyrrole levels. Supplements are often necessary.
10. How long does treatment take?
Treatment duration varies but often involves months of supplementation, with regular testing to monitor progress and adjust doses.
11. Who should consider testing for Pyrrole Disorder?
Individuals with chronic anxiety, unexplained fatigue, or sensitivity to light and sounds should consider testing, particularly if symptoms persist despite other treatments.
Meet Our Naturopaths
Our Naturopaths at Brisbane Livewell Clinic are highly experienced and committed to providing top-tier natural healthcare. Our team of highly qualified Naturopaths offers a range of interests and focus areas, ensuring that your specific health needs (and those of your family) are met with expert care, empathy and reassurance.
