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Feeding Your Brain: The Gut-Brain Connection

Last updated on 31 December 2025 by Brisbane Livewell Clinic Editorial Team

The Gut-Brain Connection: How To Feed Your Brain. If there was ever a call for Digestive and Gut Health, this is it. Yes, it’s true. Your gut is considered your “Second Brain.” The evidence is in, and because of the new scientific discoveries about the Vagus Nerve, the enteric nervous system, and the amazing influence your gut microbes can have, it’s no wonder what you eat feeds not only your body but can directly affect your brain. The Gut-Brain Connection – I find it amazing (but not too surprising). Well, it’s very complex, and to be honest, we’re still learning lots about it!

There seem to be multiple things working for the Gut-Brain Connection

Things like:

  • The Vagus Nerve that links the gut directly to the brain;
  • The “Enteric Nervous System” (A.K.A. “second brain) that helps the complex intricacies of digestion flow with little to no involvement from the actual brain;
  • The massive amount of neurotransmitters produced by the Gut;
  • The huge part of the immune system that is in the gut, but can travel throughout the body;
  • and the interactions and messages sent by the Gut Microbes.

I’ll briefly touch on these areas, and end off with a delicious recipe.

The Gut-Brain Connection: Vagus Nerve

There is a nerve that runs directly from the gut to the brain, and after reading this so far, you’ll probably get a sense of which direction 90% of the transmission is……. Not from your brain to your gut (which we used to think), but from your gut up to your brain!

The Gut-Brain Connection: The Enteric Nervous System and Neurotransmitters

Would you believe me if I told you that the gut has more nerves than your spinal cord? I knew you would! And that’s why it’s referred to as the “second brain.”

And, if you think about it, controlling the complex process of digestion (i.e. digestive enzymes, absorption of nutrients, the flow of food, etc.) should probably be done pretty “smartly”…don’t you think? Do these nerves speak to each other, and other cells? By chemical messengers called “neurotransmitters.” In fact, many of the neurotransmitters that have a strong effect on our mood are made in the gut! We see an amazing 95% of serotonin is made in your gut, not in your brain!

The Gut-Brain Connection: The Immune System of the Gut

Because eating and drinking is a huge portal where disease-causing microbes can get into your body, it makes total sense that much of our defence system would be located there too, right? Seventy-five per cent of our immune system is in our gut! And did you know that the immune cells can move throughout the entire body and cause inflammation just about anywhere? Well, if they’re “activated” by something in the gut, they can potentially wreak havoc anywhere in the body, including the potential to cause inflammation in the brain.

Gut Microbes

Your friendly gut residents. You have billions of those little guys happily living in your gut. And they do amazing things like help you digest certain foods, make certain vitamins, and even help regulate inflammation! More and more evidence shows that changes in your gut microbiota can impact your mood, and even other, more serious, mental health issues.

How do these all work together for Brain Health?

The honest answer to how these things all work together is that we really don’t know just yet. More and more studies are being done to learn more. But one thing is becoming clear. A healthy gut goes hand-in-hand with a healthy brain! So, how do you feed your brain?

Of course, a variety of minimally-processed, nutrient-dense foods is required, because no nutrients work alone. But two things that you many consider eating more of are fibre and omega-3 fats. Fibre (in fruits, veggies, nuts & seeds) help to feed your awesome gut microbes. And omega-3 fats (in fatty fish, walnuts, algae, and seeds like flax, chia, and hemp) are well known inflammation-lowering brain boosters.

Recipe (Gut food fibre, Brain food omega-3):

Blueberry Hemp Overnight Oats (Serves 2)

  • 1 cup blueberries (fresh or frozen)
  • 1 cup oats (gluten-free)
  • 1 cup almond milk
  • 1 tablespoon chia seeds
  • 2 tablespoons hemp seeds
  • ½ teaspoon cinnamon
  • 1 banana, sliced
  • ¼ cup chopped walnuts
  1. Blend blueberries in the food processor until smooth.
  2. Mix blueberries, oats, almond milk, chia seeds, hemp seeds in a bowl with a lid.
  3. Let set in the fridge overnight.
  4. Split into two bowls and top with cinnamon, banana, and walnuts.

Serve & enjoy!

Tip: Your gut microbes love to eat the fibre in the blueberries, oats, seeds, and nuts. Meanwhile, your brain loves the omega-3 fats in the seeds and nuts.


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Written by the Brisbane Livewell Clinic Editorial Team

Written by the Brisbane Livewell Clinic Editorial Team in accordance with our Editorial Policy and Content Standards.

Reviewed by Our Practitioners

Expert Review by our qualified Practitioners at Brisbane Livewell Clinic (Wavell Heights) and Brisbane Livewell Clinic (Cannon Hill). Our articles are reviewed for accuracy, AHPRA compliance (for Allied Health Services) and alignment with current evidence and best practice under our Editorial Policy and Content Standards.